Pharmaceuticals
​
• High-throughput protein crystallography with automated systems for drug discovery and drug optimisation applications.
​
• Characterising active pharmaceutical ingredients and formulations under simulated manufacturing conditions (e.g. pressure, ball milling, etc...).
​
• Characterising the structure and function of enzymes for drug development, including the location and movement of hydrogen atoms.
​
• In situ studies investigating how storage and transport conditions impact drug lifetime (e.g. accelerated ageing, humidity, temperature, UV exposure etc...).
​
• Revealing structural information about how drugs interact with therapeutic targets at the atomic level.
​
• Structural and interaction studies of colloid suspensions, micro-emulsions and micelles.
​
• Characterising the mechanisms of self-assembly in solutions.
​
• Solving solubility and stability issues for drug development and manufacturing.
​
• Studying aggregation and crystallisation phenomena.
​
• Detecting impurities.
​
• Polymorphism studies for protecting intellectual property and detecting patent infringement.
​
• Determining drug structure at the atomic level, including chirality, absolute configuration and identifying drug-molecule binding sites.
​
• Monitoring the penetration of drugs and pharmaceutical formulations into biological tissues such as the skin.